Cadoo K., M. Meyers, et al. (2019, June). “ENCORE 603: A phase II randomized study of avelumab plus entinostat versus avelumab plus placebo in patients with advanced and recurrent epithelial ovarian cancer.” Slides presented at the American Society of Clinical Oncology Annual Meeting, Chicago, IL.
Sullivan R., S. Moschos, et al. (2019, April). “Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with melanoma previously treated with anti-PD-1 therapy.” Slides presented at the American Association for Cancer Research Annual Meeting, Atlanta, GA.
Ordentlich P., L. Wang, et al. (2019, March). “Identification of gene signatures associated with response in a Phase 2 trial of entinostat (ENT) plus pembrolizumab (PEMBRO) in non-small cell lung cancer (NSCLC) patients whose disease has progressed on or after anti-PD-(L)1 therapy.” Slides presented at the American Association for Cancer Research Annual Meeting, Atlanta, GA.
Nandre R., V. Verma, et al. (2018, November). “Entinostat Increases the Frequency of Tumor-Specific Effector T-cells and Their Functionality is Enhanced by Anti-OX40 Leading to Durable anti-Tumor Effects.” Poster presented at the Society for the Immunotherapy of Cancer Annual Meeting, Washington, DC.
Hellmann M., P. Janne, et al. (2018, September). “Efficacy/safety of entinostat (ENT) and pembrolizumab (PEMBRO) in NSCLC patients previously treated with anti-PD-(L)1 therapy.” Slides presented at the IASLC 19th World Conference on Lung Cancer, Toronto, Canada.
Agarwala S. et al. (2018, June) “Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with melanoma progressing on or after a PD-1/L1 blocking antibody.” Poster presented at the American Society of Clinical Oncology Annual Meeting, Chicago, IL.
Azad N. et al. (2018, June). “ENCORE 601: A phase 2 study of entinostat in combination with pembrolizumab in patients with microsatellite stable metastatic colorectal cancer.” Poster presented at the American Society of Clinical Oncology Annual Meeting, Chicago, IL.
Gandhi L. et al. (2018, June). “Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with non-small cell lung cancer (NSCLC) previously treated with anti-PD-(L)1 therapy.” Poster presented at the American Society of Clinical Oncology Annual Meeting, Chicago, IL.
Tolcher A., M. L. Meyers, et al. (2018, April). “Safety, Efficacy, and Immune Correlates of Alternative Doses and Schedules of Entinostat Combined With Pembrolizumab in Patients With Advanced Solid Tumors – Results From SNDX-275-0141 Phase I Trial.” Slides presented at the American Association for Cancer Research Annual Meeting, Chicago, IL.
Wang L., D. Chen F., et al. (2018, April). “Enhanced Anti-tumor Activity of the Combination of Entinostat and NKTR-214 in Renal and Colon Cancer Tumor Models.” Poster presented at the American Association for Cancer Research Annual Meeting, Chicago, IL.
Krieg C., M. Nowicka, et al. (2018) “High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy.” Nat Med. 24(2), 144–153.
Pili R., D. Quinn, et at. (2017). “Immunomodulation by Entinostat in Renal Cell Carcinoma Patients Receiving High-Dose Interleukin 2: A Multicenter, Single-Arm, Phase I/II Trial (NCI-CTEP#7870).” Clin Cancer Res. 23(23), 7199-7208
Johnson M., D. Gabrilovich, et al. (2017, November). “Analysis of biomarkers from a cohort of advanced melanoma patients treated with entinostat (ENT) and pembrolizumab (PEMBRO) previously exposed to immune checkpoint inhibition.” Poster presented at the Society for the Immunotherapy of Cancer Annual Meeting, National Harbor, MD.
Gandhi L.., M. Johnson, et al. (2017, November). “ENCORE-601: Phase 1b/2 study of entinostat (ENT) in combination with pembrolizumab (PEMBRO) in patients with non-small cell lung cancer.” Poster and slides presented at the Society for the Immunotherapy of Cancer Annual Meeting, National Harbor, MD.
Orillion A., A. Hashimoto, et al. (2017). “Entinostat neutralizes myeloid derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma.” Clin Cancer Res. DOI: 10.1158/1078-0432.CCR-17-0741
Johnson M. et al. (2017, June). “ENCORE 601: A Phase 2 study of entinostat (ENT) in combination with pembrolizumab (PEMBRO) in patients with melanoma.” Poster presented at the American Society of Clinical Oncology Annual Meeting, Chicago, IL.
Johnson M., A. Adjei, et al. (2016, November). “Dose-escalation/confirmation results of ENCORE 601, a Phase 1b/2, open-label study of entinostat (ENT) in combination with pembrolizumab (PEMBRO) in patients with non–small cell lung cancer (NSCLC).” Poster presented at the Society for the Immunotherapy of Cancer Annual Meeting, National Harbor, MD.
Gameiro SR, AS Malamas, et al. (2016). “Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells.” Oncotarget. 7(7):7390-402.
Shen, L., A. Orillion, R. Pili. (2016). “Histone deacetylase inhibitors as immunomodulators in cancer therapeutics.” Epigenomics. 8(3):415-28.
Park J., S. Thomas, and P. Munster. (2015). “Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy”. Epigenomics. 7(4):641-52.
Kim, K., A. Skora, et al. (2014). “Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.” PNAS. 111(32):11774-9.
Youn JI, V. Kumar, et al. (2013). “Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.” Nat. Immunol. 14(3): 211–220.
Zhu S., C. Denman, et al. (2013). “The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells.” Pharm. Res. 32(3): 779–92.
Shen, L., M. Ciesielksi, et al. (2012). “Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.” PLoSOne. 7(1): e30815.
Juergens RA, J. Wrangle, et al. (2011). “Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.” Cancer Discov. 1(7): 598–607.